Challenges and opportunities for T cell-mediated strategies to eliminate HIV reservoirs

HIV’s ability to establish latent reservoirs of reactivation-competent virus is the major barrier to cure. Shock and kill methods consisting of latency reversing agents (LRAs) followed by elimination of reactivating cells through cytopathic effects are under active development. However, the clinical...

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Bibliographic Details
Main Authors: Mark Alan Brockman, R. Brad eJones, Zabrina Lesley Brumme
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00506/full