Challenges and opportunities for T cell-mediated strategies to eliminate HIV reservoirs
HIV’s ability to establish latent reservoirs of reactivation-competent virus is the major barrier to cure. Shock and kill methods consisting of latency reversing agents (LRAs) followed by elimination of reactivating cells through cytopathic effects are under active development. However, the clinical...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-10-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00506/full |
| _version_ | 1828913566785208320 |
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| author | Mark Alan Brockman Mark Alan Brockman R. Brad eJones Zabrina Lesley Brumme Zabrina Lesley Brumme |
| author_facet | Mark Alan Brockman Mark Alan Brockman R. Brad eJones Zabrina Lesley Brumme Zabrina Lesley Brumme |
| author_sort | Mark Alan Brockman |
| collection | DOAJ |
| description | HIV’s ability to establish latent reservoirs of reactivation-competent virus is the major barrier to cure. Shock and kill methods consisting of latency reversing agents (LRAs) followed by elimination of reactivating cells through cytopathic effects are under active development. However, the clinical efficacy of LRAs remains to be established. Moreover, recent studies indicate that reservoirs may not be reduced efficiently by either viral cytopathic or CD8+ T-cell-mediated mechanisms. In this perspective, we highlight challenges to T-cell-mediated elimination of HIV reservoirs, including characteristics of responding T-cells, aspects of the cellular reservoirs and properties of the latent virus itself. We also discuss potential strategies to overcome these challenges by targeting the antiviral activity of T-cells towards appropriate viral antigens following latency. |
| first_indexed | 2024-12-13T19:39:21Z |
| format | Article |
| id | doaj.art-2263e5ea3e3d439f824457e98ad7117e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T19:39:21Z |
| publishDate | 2015-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2263e5ea3e3d439f824457e98ad7117e2022-12-21T23:33:44ZengFrontiers Media S.A.Frontiers in Immunology1664-32242015-10-01610.3389/fimmu.2015.00506161087Challenges and opportunities for T cell-mediated strategies to eliminate HIV reservoirsMark Alan Brockman0Mark Alan Brockman1R. Brad eJones2Zabrina Lesley Brumme3Zabrina Lesley Brumme4Simon Fraser UniversityBritish Columbia Centre for Excellence in HIV/AIDSGeorge Washington UniversitySimon Fraser UniversityBritish Columbia Centre for Excellence in HIV/AIDSHIV’s ability to establish latent reservoirs of reactivation-competent virus is the major barrier to cure. Shock and kill methods consisting of latency reversing agents (LRAs) followed by elimination of reactivating cells through cytopathic effects are under active development. However, the clinical efficacy of LRAs remains to be established. Moreover, recent studies indicate that reservoirs may not be reduced efficiently by either viral cytopathic or CD8+ T-cell-mediated mechanisms. In this perspective, we highlight challenges to T-cell-mediated elimination of HIV reservoirs, including characteristics of responding T-cells, aspects of the cellular reservoirs and properties of the latent virus itself. We also discuss potential strategies to overcome these challenges by targeting the antiviral activity of T-cells towards appropriate viral antigens following latency.http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00506/fullImmune EvasionT cellsimmune-based therapyCTL escapeHIV latency |
| spellingShingle | Mark Alan Brockman Mark Alan Brockman R. Brad eJones Zabrina Lesley Brumme Zabrina Lesley Brumme Challenges and opportunities for T cell-mediated strategies to eliminate HIV reservoirs Frontiers in Immunology Immune Evasion T cells immune-based therapy CTL escape HIV latency |
| title | Challenges and opportunities for T cell-mediated strategies to eliminate HIV reservoirs |
| title_full | Challenges and opportunities for T cell-mediated strategies to eliminate HIV reservoirs |
| title_fullStr | Challenges and opportunities for T cell-mediated strategies to eliminate HIV reservoirs |
| title_full_unstemmed | Challenges and opportunities for T cell-mediated strategies to eliminate HIV reservoirs |
| title_short | Challenges and opportunities for T cell-mediated strategies to eliminate HIV reservoirs |
| title_sort | challenges and opportunities for t cell mediated strategies to eliminate hiv reservoirs |
| topic | Immune Evasion T cells immune-based therapy CTL escape HIV latency |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00506/full |
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