A Supramolecular Interaction of a Ruthenium Complex With Calf-Thymus DNA: A Ligand Binding Approach by NMR Spectroscopy

A Supramolecular Interaction of a Ruthenium Complex With Calf-Thymus DNA: A Ligand Binding Approach by NMR Spectroscopy

Lawsone itself exhibits interesting biological activities, and its complexation with a metal center can improve the potency. In this context a cytotoxic Ru-complex, [Ru(law)(dppb)(bipy)] (law = lawsone, dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2′-bipyridine), named as CBLAU, was prepared...

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Bibliographic Details
Main Authors: Flávio Vinícius Crizóstomo Kock, Analu Rocha Costa, Katia Mara de Oliveira, Alzir Azevedo Batista, Antônio Gilberto Ferreira, Tiago Venâncio
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Chemistry
Subjects:
binding interactions
lawsone
ruthenium complex
anti-cancer
CT-DNA
NMR
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00762/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00762/full

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