Restoring GABAB receptor expression in the ventral tegmental area of methamphetamine addicted mice inhibits locomotor sensitization and drug seeking behavior

Restoring GABAB receptor expression in the ventral tegmental area of methamphetamine addicted mice inhibits locomotor sensitization and drug seeking behavior

Repeated exposure to psychostimulants such as methamphetamine (METH) induces neuronal adaptations in the mesocorticolimbic dopamine system, including the ventral tegmental area (VTA). These changes lead to persistently enhanced neuronal activity causing increased dopamine release and addictive pheno...

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Bibliographic Details
Main Authors: Mohammad Hleihil, Dietmar Benke
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
addiction
GABA receptor
interfering peptide
methamphetamine
protein phosphatase 2A
ventral tegmental area (VTA)
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1347228/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2024.1347228/full

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