2D NMR Analysis as a Sensitive Tool for Evaluating the Higher-Order Structural Integrity of Monoclonal Antibody against COVID-19

2D NMR Analysis as a Sensitive Tool for Evaluating the Higher-Order Structural Integrity of Monoclonal Antibody against COVID-19

The higher-order structure (HOS) of protein therapeutics has been confirmed as a critical quality parameter. In this study, we compared 2D <sup>1</sup>H-<sup>13</sup>C ALSOFAST-HMQC NMR spectra with immunochemical ELISA-based analysis to evaluate their sensitivity in assessin...

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Bibliographic Details
Main Authors: Francesca Cantini, Emanuele Andreano, Ida Paciello, Veronica Ghini, Francesco Berti, Rino Rappuoli, Lucia Banci
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceutics
Subjects:
monoclonal antibodies
nuclear magnetic resonance
higher order structure
COVID-19
Online Access:https://www.mdpi.com/1999-4923/14/10/1981

Internet

https://www.mdpi.com/1999-4923/14/10/1981

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