Comprehensive approach for identification of functional FCGR2C alleles resulting in protein expression as a determinant for predicting predisposition to autoimmunity

Comprehensive approach for identification of functional FCGR2C alleles resulting in protein expression as a determinant for predicting predisposition to autoimmunity

Abstract The balance of activating and inhibitory signals from the low affinity Fc gamma receptors modulates immune responses triggered by IgG antibody‐immune complexes. In homeostasis, this leads to antigen clearance, while in autoimmune diseases to unwanted immune response. Besides the activating...

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Bibliographic Details
Main Authors: Dorit Lehmann, Sabine Unterthurner, Verena Berg, Karin Hock, Padmapriya Ponnuswamy, Mantas Malisauskas, Brian A. Crowe, Bekir Erguener, Christoph Bock, Greg Hather, Birgit M. Reipert, Ivan Bilic
Format: Article
Language:English
Published: Wiley 2021-12-01
Series:ImmunoMedicine
Subjects:
copy number variation
FCGR2C expression
low affinity immunoglobulin receptors
SNP
systemic lupus erythematosus
Online Access:https://doi.org/10.1002/imed.1027

Internet

https://doi.org/10.1002/imed.1027

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