Design, synthesis, 2D-QSAR, molecular dynamic simulation, and biological evaluation of topiramate–phenolic acid conjugates as PPARγ inhibitors

Design, synthesis, 2D-QSAR, molecular dynamic simulation, and biological evaluation of topiramate–phenolic acid conjugates as PPARγ inhibitors

Abstract Background Obesity is a precursor for many co-morbid diseases. One of the main triggering factors for obesity is the abnormal expansion of white adipose tissue characterized by high rates of genesis and differentiation of precursor cells into mature adipocytes. As a result, targeting adipog...

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Bibliographic Details
Main Authors: Ipsa Padhy, Biswajit Banerjee, P. Ganga Raju Achary, Pramodkumar P. Gupta, Tripti Sharma
Format: Article
Language:English
Published: SpringerOpen 2024-03-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
PPARγ
2D-QSAR
Molecular docking
Molecular dynamic simulation
Antiobesity
Online Access:https://doi.org/10.1186/s43094-024-00617-1

Internet

https://doi.org/10.1186/s43094-024-00617-1

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