Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion[S]

Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion[S]

We examined the effect of Niemann-Pick disease type 2 (NPC2) protein and some late endosomal lipids [sphingomyelin, ceramide and bis(monoacylglycero)phosphate (BMP)] on cholesterol transfer and membrane fusion. Of all lipid-binding proteins tested, only NPC2 transferred cholesterol at a substantial...

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Bibliographic Details
Main Authors: Misbaudeen Abdul-Hammed, Bernadette Breiden, Matthew A. Adebayo, Jonathan O. Babalola, Günter Schwarzmann, Konrad Sandhoff
Format: Article
Language:English
Published: Elsevier 2010-07-01
Series:Journal of Lipid Research
Subjects:
Niemann-Pick disease type 2 protein
ceramide
sphingomyelin
late endosomes
sphingolipid activator proteins
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520370978

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http://www.sciencedirect.com/science/article/pii/S0022227520370978

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