Development and Characterization of Eudragit<sup>®</sup> EPO-Based Solid Dispersion of Rosuvastatin Calcium to Foresee the Impact on Solubility, Dissolution and Antihyperlipidemic Activity

Development and Characterization of Eudragit<sup>®</sup> EPO-Based Solid Dispersion of Rosuvastatin Calcium to Foresee the Impact on Solubility, Dissolution and Antihyperlipidemic Activity

Poor solubility is the major challenge involved in the formulation development of new chemical entities (NCEs), as more than 40% of NCEs are practically insoluble in water. Solid dispersion (SD) is a promising technology for improving dissolution and, thereby, the bioavailability of poorly soluble d...

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Bibliographic Details
Main Authors: Sana Inam, Muhammad Irfan, Noor ul ain Lali, Haroon Khalid Syed, Sajid Asghar, Ikram Ullah Khan, Salah-Ud-Din Khan, Muhammad Shahid Iqbal, Imran Zaheer, Ahmed Khames, Heba A. Abou-Taleb, Mohammad A. S. Abourehab
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceuticals
Subjects:
solid dispersion
rosuvastatin calcium
Eudragit<sup>®</sup> EPO
docking
improved solubility
anti-hyperlipidemic activity
Online Access:https://www.mdpi.com/1424-8247/15/4/492

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https://www.mdpi.com/1424-8247/15/4/492

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