Acting on the CFTR Membrane-Spanning Domains Interface Rescues Some Misfolded Mutants

Acting on the CFTR Membrane-Spanning Domains Interface Rescues Some Misfolded Mutants

ABC transporters are large membrane proteins sharing a complex architecture, which comprises two nucleotide-binding domains (NBDs) and two membrane-spanning domains (MSDs). These domains are susceptible to mutations affecting their folding and assembly. In the CFTR (ABCC7) protein, a groove has been...

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Bibliographic Details
Main Authors: Nesrine Baatallah, Ahmad Elbahnsi, Benoit Chevalier, Solène Castanier, Jean-Paul Mornon, Iwona Pranke, Aleksander Edelman, Isabelle Sermet-Gaudelus, Isabelle Callebaut, Alexandre Hinzpeter
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
CFTR
ABC transporter
ABCC
ABCB
structure function relationships
molecular dynamics
Online Access:https://www.mdpi.com/1422-0067/23/24/16225

Internet

https://www.mdpi.com/1422-0067/23/24/16225

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