Crystal structure of human nicotinic acid phosphoribosyltransferase

Crystal structure of human nicotinic acid phosphoribosyltransferase

Nicotinic acid phosphoribosyltransferase (EC 2.4.2.11) (NaPRTase) is the rate‐limiting enzyme in the three‐step Preiss–Handler pathway for the biosynthesis of NAD. The enzyme catalyzes the conversion of nicotinic acid (Na) and 5‐phosphoribosyl‐1‐pyrophosphate (PRPP) to nicotinic acid mononucleotide...

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Bibliographic Details
Main Authors: Ada Serena Marletta, Alberto Massarotti, Giuseppe Orsomando, Giulio Magni, Menico Rizzi, Silvia Garavaglia
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:FEBS Open Bio
Subjects:
Nicotinic Acid
Preiss–Handler pathway
NAD biosynthesis
Phosphoribosyltransferase
FK866
Recycling NAD pathway
Online Access:https://doi.org/10.1016/j.fob.2015.05.002

Internet

https://doi.org/10.1016/j.fob.2015.05.002

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