β-Hydroxylation of α-amino-β-hydroxylbutanoyl-glycyluridine catalyzed by a nonheme hydroxylase ensures the maturation of caprazamycin

β-Hydroxylation of α-amino-β-hydroxylbutanoyl-glycyluridine catalyzed by a nonheme hydroxylase ensures the maturation of caprazamycin

Caprazamycin is a nucleoside antibiotic that can interrupt bacterial peptidoglycan biosynthesis, but the biosynthesis of caprazamycin is not fully understood yet. Here, the authors characterize five key enzymes from caprazamycin/muraymycin gene cluster, particularly nonheme αKG-dependent enzyme Cpz1...

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Bibliographic Details
Main Authors: Saeid Malek Zadeh, Mei-Hua Chen, Zhe-Chong Wang, Elahe K. Astani, I-Wen Lo, Kuan-Hung Lin, Ning-Shian Hsu, Kamal Adhikari, Syue-Yi Lyu, Hsin-Ying Tsai, Yuma Terasawa, Miyuki Yabe, Kazuki Yamamoto, Satoshi Ichikawa, Tsung-Lin Li
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-022-00703-6

Internet

https://doi.org/10.1038/s42004-022-00703-6

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