Parent-of-origin effects implicate epigenetic regulation of experimental autoimmune encephalomyelitis and identify imprinted Dlk1 as a novel risk gene.

Parent-of-origin effects implicate epigenetic regulation of experimental autoimmune encephalomyelitis and identify imprinted Dlk1 as a novel risk gene.

Parent-of-origin effects comprise a range of genetic and epigenetic mechanisms of inheritance. Recently, detection of such effects implicated epigenetic mechanisms in the etiology of multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system. We here sought to dissect the...

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Bibliografski detalji
Glavni autori: Pernilla Stridh, Sabrina Ruhrmann, Petra Bergman, Mélanie Thessén Hedreul, Sevasti Flytzani, Amennai Daniel Beyeen, Alan Gillett, Nina Krivosija, Johan Öckinger, Anne C Ferguson-Smith, Maja Jagodic
Format: Članak
Jezik:English
Izdano: Public Library of Science (PLoS) 2014-03-01
Serija:PLoS Genetics
Online pristup:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1004265&type=printable

Internet

https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1004265&type=printable

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