Thiaplakortone B attenuates RANKL‐induced NF‐κB and MAPK signaling and dampens OVX‐induced bone loss in mice

Thiaplakortone B attenuates RANKL‐induced NF‐κB and MAPK signaling and dampens OVX‐induced bone loss in mice

Osteoclasts play an important role in maintaining the relative stability of bone mass. Abnormal number and function of osteoclasts are closely related to osteoporosis and osteolytic diseases. Thiaplakortone B (TPB), a natural compound derived from the Great Barrier Reef sponge Plakortis lita, has be...

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Bibliographic Details
Main Authors: Qingqing Wang, Delong Chen, Yining Wang, Chenlin Dong, Jian Liu, Kai Chen, Fangming Song, Chao Wang, Jinbo Yuan, Rohan A. Davis, Vincent Kuek, Haiming Jin, Jiake Xu
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Marine natural product
Thiaplakortone B
Osteoclastogenesis
NF‐κB
MAPK
Osteoporosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222010113

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http://www.sciencedirect.com/science/article/pii/S0753332222010113

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