The N-acetyltransferase 10 inhibitor [11C]remodelin: synthesis and preliminary positron emission tomography study in mice

The N-acetyltransferase 10 inhibitor [11C]remodelin: synthesis and preliminary positron emission tomography study in mice

Abstract Background 4-(4-Cyanophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole (remodelin) is a potent N-acetyltransferase 10 (NAT10) inhibitor. This compound inhibits tumors and weakens tumor resistance to antitumor drugs. Moreover, remodelin has been found to enhance healthspan in an animal model...

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Bibliographic Details
Main Authors: Rui Luo, Yiding Zhang, Katsushi Kumata, Lin Xie, Yusuke Kurihara, Masanao Ogawa, Tomomi Kokufuta, Nobuki Nengaki, Feng Wang, Ming-Rong R. Zhang
Format: Article
Language:English
Published: SpringerOpen 2025-01-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
[11C]remodelin, Radiosynthesis
Hydrogen [11C]cyanide
Positron emission tomography
Online Access:https://doi.org/10.1186/s41181-025-00330-1

Internet

https://doi.org/10.1186/s41181-025-00330-1

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