Punicalagin’s Protective Effects on Parkinson’s Progression in Socially Isolated and Socialized Rats: Insights into Multifaceted Pathway

Punicalagin’s Protective Effects on Parkinson’s Progression in Socially Isolated and Socialized Rats: Insights into Multifaceted Pathway

Parkinson’s disease (PD) is a gradual deterioration of dopaminergic neurons, leading to motor impairments. Social isolation (SI), a recognized stressor, has recently gained attention as a potential influencing factor in the progress of neurodegenerative illnesses. We aimed to investigate the intrica...

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Bibliographic Details
Main Authors: Hoda A. Salem, Karema Abu-Elfotuh, Sharifa Alzahrani, Nermin I. Rizk, Howaida S. Ali, Nehal Elsherbiny, Alhanouf Aljohani, Ahmed M. E. Hamdan, Panneerselvam Chellasamy, Nada S. Abdou, Ayah M. H. Gowifel, Alshaymaa Darwish, Osama Mohamed Ibrahim, Zakaria Y. Abd Elmageed
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Pharmaceutics
Subjects:
Parkinson’s disease
social isolation
PUN
HMGB1/RAGE/TLR4/NF-ᴋB/NLRP3
PI3K/AKT/GSK-3β/CREB
AMPK/SIRT-1
Online Access:https://www.mdpi.com/1999-4923/15/10/2420

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https://www.mdpi.com/1999-4923/15/10/2420

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