Third-Party Allogeneic Mesenchymal Stromal Cells Prevent Rejection in a Pre-sensitized High-Risk Model of Corneal Transplantation

Third-Party Allogeneic Mesenchymal Stromal Cells Prevent Rejection in a Pre-sensitized High-Risk Model of Corneal Transplantation

High-risk cornea transplant recipients represent a patient population with significant un-met medical need for more effective therapies to prevent immunological graft rejection due to heightened anti-donor immune response. In this study, a rat model of pre-existing anti-donor immunity was developed...

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Bibliographic Details
Main Authors: Paul Lohan, Nick Murphy, Oliver Treacy, Kevin Lynch, Maurice Morcos, Bingling Chen, Aideen E. Ryan, Matthew D. Griffin, Thomas Ritter
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
mesenchymal stromal cells
cornea transplantation
high-risk
pre-sensitization
regulatory T cells
immunomodulation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02666/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02666/full

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