Network-based analysis of heterogeneous patient-matched brain and extracranial melanoma metastasis pairs reveals three homogeneous subgroups

Network-based analysis of heterogeneous patient-matched brain and extracranial melanoma metastasis pairs reveals three homogeneous subgroups

Melanoma, the deadliest form of skin cancer, can metastasize to different organs. Molecular differences between brain and extracranial melanoma metastases are poorly understood. Here, promoter methylation and gene expression of 11 heterogeneous patient-matched pairs of brain and extracranial metasta...

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Bibliographic Details
Main Authors: Konrad Grützmann, Theresa Kraft, Matthias Meinhardt, Friedegund Meier, Dana Westphal, Michael Seifert
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Computational cancer biology
Melanoma metastasis
Gene regulatory network inference
Network-based impact propagation
Personalized network-based gene expression and promoter methylation data analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037024000370

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http://www.sciencedirect.com/science/article/pii/S2001037024000370

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