Extracellular high molecular weight α-synuclein oligomers induce cell death by disrupting the plasma membrane

Extracellular high molecular weight α-synuclein oligomers induce cell death by disrupting the plasma membrane

Abstract α-Synuclein (αS), the causative protein of Parkinson’s disease and other α-synucleinopathies, aggregates from a low molecular weight form (LMW-αS) to a high molecular weight αS oligomer (HMW-αSo). Aggregated αS accumulates intracellularly, induces intrinsic apoptosis, is released extracellu...

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Bibliographic Details
Main Authors: Naohito Ito, Mayumi Tsuji, Naoki Adachi, Shiro Nakamura, Avijite Kumer Sarkar, Kensuke Ikenaka, César Aguirre, Atsushi Michael Kimura, Yuji Kiuchi, Hideki Mochizuki, David B. Teplow, Kenjiro Ono
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-023-00583-0

Internet

https://doi.org/10.1038/s41531-023-00583-0

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