Microglial depletion disrupts normal functional development of adult-born neurons in the olfactory bulb

Microglia play key roles in regulating synapse development and refinement in the developing brain, but it is unknown whether they are similarly involved during adult neurogenesis. By transiently depleting microglia from the healthy adult mouse brain, we show that microglia are necessary for the norm...

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Bibliographic Details
Main Authors: Jenelle Wallace, Julia Lord, Lasse Dissing-Olesen, Beth Stevens, Venkatesh N Murthy
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/50531