Interpreting frequency responses to dose-conserved pulsatile input signals in simple cell signaling motifs.

Many hormones are released in pulsatile patterns. This pattern can be modified, for instance by changing pulse frequency, to encode relevant physiological information. Often other properties of the pulse pattern will also change with frequency. How do signaling pathways of cells targeted by these ho...

Full description

Bibliographic Details
Main Authors: Patrick A Fletcher, Frédérique Clément, Alexandre Vidal, Joel Tabak, Richard Bertram
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3991699?pdf=render