Design, Synthesis and Biological Evaluation of α-Synuclein Proteolysis-Targeting Chimeras

Design, Synthesis and Biological Evaluation of α-Synuclein Proteolysis-Targeting Chimeras

α-Synuclein aggregation under pathological conditions is one of the causes of related neurodegenerative diseases. PROTACs (proteolysis targeting chimeras) are bifunctional small molecules that induce a post-translational erasure of proteins via the ubiquitination of target proteins by E3 ubiquitin l...

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Bibliographic Details
Main Authors: Tianzhi Wen, Jian Chen, Wenqian Zhang, Jiyan Pang
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Molecules
Subjects:
α-synuclein
protein aggregates
PROTAC (proteolysis-targeting chimera)
Online Access:https://www.mdpi.com/1420-3049/28/11/4458

Internet

https://www.mdpi.com/1420-3049/28/11/4458

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