Tumor Apolipoprotein E is a key checkpoint blocking anti-tumor immunity in mouse melanoma

Tumor Apolipoprotein E is a key checkpoint blocking anti-tumor immunity in mouse melanoma

Immunotherapy is a key modality in the treatment of cancer, but many tumors remain immune resistant. The classic mouse model of B16-F10 melanoma is immune resistant even in the face of checkpoint inhibition. Apolipoprotein E (apoE), a known immune suppressant is strikingly elevated in many human tum...

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Bibliographic Details
Main Authors: Xiaofang Wu, Priya Srinivasan, Mousumi Basu, Peng Zhang, Michele Saruwatari, Bernice Thommandru, Ashley Jacobi, Mark Behlke, Anthony Sandler
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
apoE
immune-checkpoint
melanoma
T cells
dendritic cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.991790/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.991790/full

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