RhoA‐ROCK competes with YAP to regulate amoeboid breast cancer cell migration in response to lymphatic‐like flow

RhoA‐ROCK competes with YAP to regulate amoeboid breast cancer cell migration in response to lymphatic‐like flow

Abstract Lymphatic drainage generates force that induces prostate cancer cell motility via activation of Yes‐associated protein (YAP), but whether this response to fluid force is conserved across cancer types is unclear. Here, we show that shear stress corresponding to fluid flow in the initial lymp...

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Bibliographic Details
Main Authors: Amina Mohammadalipour, Miguel F. Diaz, Megan Livingston, Adesuwa Ewere, Allen Zhou, Paulina D. Horton, Loretta T. Olamigoke, John M. Lamar, John P. Hagan, Hyun J. Lee, Pamela L. Wenzel
Format: Article
Language:English
Published: Wiley 2022-05-01
Series:FASEB BioAdvances
Subjects:
actomyosin cytoskeleton
biomechanical force
ECM–receptor interactions
hippo
mechanotransduction
motility
Online Access:https://doi.org/10.1096/fba.2021-00055

Internet

https://doi.org/10.1096/fba.2021-00055

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