Enhanced IL-17 Producing and Maintained Cytolytic Effector Functions of Gut Mucosal CD161<sup>+</sup>CD8<sup>+</sup> T Cells in SIV-Infected Rhesus Macaques

Enhanced IL-17 Producing and Maintained Cytolytic Effector Functions of Gut Mucosal CD161<sup>+</sup>CD8<sup>+</sup> T Cells in SIV-Infected Rhesus Macaques

Previous studies have indicated that the loss of CD161-expressing CD4<sup>+</sup> Th17 cells is linked to the progression of chronic HIV. These cells are significantly depleted in peripheral blood and gut mucosa of HIV-infected individuals, contributing to inflammation and disruption of...

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Bibliographic Details
Main Authors: Siva Thirugnanam, Edith M. Walker, Faith Schiro, Pyone P. Aye, Jay Rappaport, Namita Rout
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Viruses
Subjects:
mucosal immunity
T cells
CD161
SIV
IL-17
TNF-α
Online Access:https://www.mdpi.com/1999-4915/15/9/1944

Internet

https://www.mdpi.com/1999-4915/15/9/1944

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