Dysfunctional Glymphatic System with Disrupted Aquaporin 4 Expression Pattern on Astrocytes Causes Bacterial Product Accumulation in the CSF during Pneumococcal Meningitis

Dysfunctional Glymphatic System with Disrupted Aquaporin 4 Expression Pattern on Astrocytes Causes Bacterial Product Accumulation in the CSF during Pneumococcal Meningitis

ABSTRACT Pneumococcal meningitis, inflammation of the meninges due to an infection of the Central Nervous System caused by Streptococcus pneumoniae (the pneumococcus), is the most common form of community-acquired bacterial meningitis globally. Aquaporin 4 (AQP4) water channels on astrocytic end fee...

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Bibliographic Details
Main Authors: Jaqueline S. Generoso, Sigrun Thorsdottir, Allan Collodel, Diogo Dominguini, Roberta R. E. Santo, Fabricia Petronilho, Tatiana Barichello, Federico Iovino
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:mBio
Subjects:
meningitis
Streptococcus pneumoniae
glymphatic system
neuroinflammation
neuronal damage
aquaporin 4
Online Access:https://journals.asm.org/doi/10.1128/mbio.01886-22

Internet

https://journals.asm.org/doi/10.1128/mbio.01886-22

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