Global biogeographic sampling of bacterial secondary metabolism

Recent bacterial (meta)genome sequencing efforts suggest the existence of an enormous untapped reservoir of natural-product-encoding biosynthetic gene clusters in the environment. Here we use the pyro-sequencing of PCR amplicons derived from both nonribosomal peptide adenylation domains and polyketi...

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Bibliographic Details
Main Authors: Zachary Charlop-Powers, Jeremy G Owen, Boojala Vijay B Reddy, Melinda A Ternei, Denise O Guimarães, Ulysses A de Frias, Monica T Pupo, Prudy Seepe, Zhiyang Feng, Sean F Brady
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-01-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/05048