Zephycandidine A and Synthetic Analogues—Synthesis and Evaluation of Biological Activity

Zephycandidine A and Synthetic Analogues—Synthesis and Evaluation of Biological Activity

A convenient total synthesis of the imidazo[1,2-f]phenanthridine-type Amaryllidaceae alkaloid zephycandidine A (<b>3</b>) was developed, which further allowed us to perform modifications of substituents on benzenoid ring A and imidazole ring D. The biological activities of all synthesize...

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Bibliographic Details
Main Authors: Thomas Klaßmüller, Florian Lengauer, Julia Blenninger, Franz Geisslinger, Karin Bartel, Franz Bracher
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Molecules
Subjects:
zephycandidine A
alkaloid
total synthesis
structure–activity relationship
leukemia
cell death
Online Access:https://www.mdpi.com/1420-3049/30/3/752

Internet

https://www.mdpi.com/1420-3049/30/3/752

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