Characterization of genomic alterations and neoantigens and analysis of immune infiltration identified therapeutic and prognostic biomarkers in adenocarcinoma at the gastroesophageal junction

Characterization of genomic alterations and neoantigens and analysis of immune infiltration identified therapeutic and prognostic biomarkers in adenocarcinoma at the gastroesophageal junction

ObjectivesAdenocarcinoma at the gastroesophageal junction (ACGEJ) refers to a malignant tumor that occurs at the esophagogastric junction. Despite some progress in targeted therapies for HER2, FGFR2, EGFR, MET, Claudin 18.2 and immune checkpoints in ACGEJ tumors, the 5-year survival rate of patients...

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Bibliographic Details
Main Authors: Yueqiong Lao, Yuqian Wang, Jie Yang, Tianyuan Liu, Yuling Ma, Yingying Luo, Yanxia Sun, Kai Li, Xuan Zhao, Xiangjie Niu, Yiyi Xi, Ce Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Oncology
Subjects:
adenocarcinoma at the gastroesophageal junction
genome and transcriptome
tumor neoantigens
CD8+ T cells
therapeutic biomarkers
prognostic prediction
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.941868/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.941868/full

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