Disruption of adipocyte HIF-1α improves atherosclerosis through the inhibition of ceramide generation

Disruption of adipocyte HIF-1α improves atherosclerosis through the inhibition of ceramide generation

Atherosclerosis is a chronic multifactorial cardiovascular disease. Western diets have been reported to affect atherosclerosis through regulating adipose function. In high cholesterol diet-fed ApoE–/– mice, adipocyte HIF-1α deficiency or direct inhibition of HIF-1α by the selective pharmacological H...

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Bibliographic Details
Main Authors: Pengcheng Wang, Guangyi Zeng, Yu Yan, Song-yang Zhang, Yongqiang Dong, Yangming Zhang, Xingzhong Zhang, Huiying Liu, Zhipeng Zhang, Changtao Jiang, Yanli Pang
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
HIF-1α
SMPD3
Ceramide
PX-478
Adipocyte
Cholesterol
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521003907

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http://www.sciencedirect.com/science/article/pii/S2211383521003907

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