Targeting DNA Damage Repair Mechanisms in Pancreas Cancer

Targeting DNA Damage Repair Mechanisms in Pancreas Cancer

Impaired DNA damage repair (DDR) is increasingly recognised as a hallmark in pancreatic ductal adenocarcinoma (PDAC). It is estimated that around 14% of human PDACs harbour mutations in genes involved in DDR, including, amongst others, <i>BRCA1/2</i>, <i>PALB2</i>, <i>A...

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Bibliographic Details
Main Authors: Lukas Perkhofer, Talia Golan, Pieter-Jan Cuyle, Tamara Matysiak-Budnik, Jean-Luc Van Laethem, Teresa Macarulla, Estelle Cauchin, Alexander Kleger, Alica K. Beutel, Johann Gout, Albrecht Stenzinger, Eric Van Cutsem, Joaquim Bellmunt, Pascal Hammel, Eileen M. O’Reilly, Thomas Seufferlein
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
DNA damage repair
pancreatic ductal adenocarcinoma
<i>BRCA1/2</i>
PARP inhibition
platinum
homologous repair deficiency
Online Access:https://www.mdpi.com/2072-6694/13/17/4259

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https://www.mdpi.com/2072-6694/13/17/4259

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