Diverse hematological malignancies including hodgkin-like lymphomas develop in chimeric MHC class II transgenic mice.

Diverse hematological malignancies including hodgkin-like lymphomas develop in chimeric MHC class II transgenic mice.

A chimeric HLA-DR4-H2-E (DR4) homozygous transgenic mouse line spontaneously develops diverse hematological malignancies with high frequency (70%). The majority of malignancies were distributed equally between T and B cell neoplasms and included lymphoblastic T cell lymphoma (LTCL), lymphoblastic B...

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Bibliographic Details
Main Authors: Silke H Raffegerst, Gabriele Hoelzlwimmer, Sandra Kunder, Josef Mysliwietz, Leticia Quintanilla-Martinez, Dolores J Schendel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2796171?pdf=render

Internet

http://europepmc.org/articles/PMC2796171?pdf=render

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