Nerve Growth Factor Neutralization Promotes Oligodendrogenesis by Increasing miR-219a-5p Levels

Nerve Growth Factor Neutralization Promotes Oligodendrogenesis by Increasing miR-219a-5p Levels

In the brain, the neurotrophin Nerve growth factor (NGF) regulates not only neuronal survival and differentiation, but also glial and microglial functions and neuroinflammation. NGF is known to regulate oligodendrogenesis, reducing myelination in the central nervous system (CNS). In this study, we f...

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Bibliographic Details
Main Authors: Rossella Brandi, Marietta Fabiano, Corinna Giorgi, Ivan Arisi, Federico La Regina, Francesca Malerba, Sabrina Turturro, Andrea Ennio Storti, Flavia Ricevuti, Susanna Amadio, Cinzia Volontè, Simona Capsoni, Raffaella Scardigli, Mara D’Onofrio, Antonino Cattaneo
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
Nerve growth factor (NGF)
miR-219a-5p
oligodendrogenesis
myelin
demyelinating diseases
microRNAs
Online Access:https://www.mdpi.com/2073-4409/10/2/405

Internet

https://www.mdpi.com/2073-4409/10/2/405

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