Testing Mitochondrial-Targeted Drugs in iPSC-RPE from Patients with Age-Related Macular Degeneration

Testing Mitochondrial-Targeted Drugs in iPSC-RPE from Patients with Age-Related Macular Degeneration

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. No universally effective treatments exist for atrophic or “dry” AMD, which results from loss of the retinal pigment epithelium (RPE) and photoreceptors and accounts for ≈80% of all AMD patients. Prior studies pr...

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Bibliographic Details
Main Authors: Mara C. Ebeling, Zhaohui Geng, Madilyn R. Stahl, Rebecca J. Kapphahn, Heidi Roehrich, Sandra R. Montezuma, Deborah A. Ferrington, James R. Dutton
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Pharmaceuticals
Subjects:
human-induced pluripotent stem cells
retinal pigment epithelium
age-related macular degeneration
personalized drug testing
Online Access:https://www.mdpi.com/1424-8247/15/1/62

Internet

https://www.mdpi.com/1424-8247/15/1/62

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