PGE2 Modulates GABAA Receptors via an EP1 Receptor-Mediated Signaling Pathway

PGE2 Modulates GABAA Receptors via an EP1 Receptor-Mediated Signaling Pathway

Aims: PGE2 is one of the most abundant prostanoids in mammalian tissues, but its effect on neuronal receptors has not been well investigated. This study examines the effect of PGE2 on GABAA receptor currents in rat cerebellar granule neurons. Methods: GABAA currents were recorded using a patch-clamp...

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Bibliographic Details
Main Authors: Guang Yang, Wen-Hao Dong, Chang-Long Hu, Yan-Ai Mei
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Cerebellar granule cells
EP receptor
PKC
PGE2
GABAA receptors
Online Access:http://www.karger.com/Article/FullText/430143

Internet

http://www.karger.com/Article/FullText/430143

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