Asbestos accelerates disease onset in a genetic model of malignant pleural mesothelioma

Asbestos accelerates disease onset in a genetic model of malignant pleural mesothelioma

Hypothesis: Asbestos-driven inflammation contributes to malignant pleural mesothelioma beyond the acquisition of rate-limiting mutations.Methods: Genetically modified conditional allelic mice that were previously shown to develop mesothelioma in the absence of exposure to asbestos were induced with...

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Bibliographic Details
Main Authors: Pooyeh Farahmand, Katarina Gyuraszova, Claire Rooney, Ximena L. Raffo-Iraolagoitia, Geeshath Jayasekera, Ann Hedley, Emma Johnson, Tatyana Chernova, Gaurav Malviya, Holly Hall, Tiziana Monteverde, Kevin Blyth, Rodger Duffin, Leo M. Carlin, David Lewis, John Le Quesne, Marion MacFarlane, Daniel J. Murphy
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Toxicology
Subjects:
mesothelioma
asbestos
cancer therapy
GM mouse model
macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2023.1200650/full

Internet

https://www.frontiersin.org/articles/10.3389/ftox.2023.1200650/full

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