Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis

Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis

We previously reported that Tangshen formula (TSF), a Chinese herbal medicine for diabetic kidney disease (DKD) therapy, imparts renal protective effects. However, the underlying mechanisms of these effects remain unclear. Pyroptosis is a form of programmed cell death that can be triggered by the NL...

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Bibliographic Details
Main Authors: Nan Li, Tingting Zhao, Yongtong Cao, Haojun Zhang, Liang Peng, Yan Wang, Xuefeng Zhou, Qian Wang, Jialin Li, Meihua Yan, Xi Dong, Hailing Zhao, Ping Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
tangshen formula
diabetic kidney disease
NLRP3 inflammasome
pyroptosis
reactive oxygen species
thioredoxin interacting protein
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.623489/full

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https://www.frontiersin.org/articles/10.3389/fphar.2020.623489/full

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