Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation

Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation

Abstract Structural resolution of protein interactions enables mechanistic and functional studies as well as interpretation of disease variants. However, structural data is still missing for most protein interactions because we lack computational and experimental tools at scale. This is particularly...

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Bibliographic Details
Main Authors: Chop Yan Lee, Dalmira Hubrich, Julia K Varga, Christian Schäfer, Mareen Welzel, Eric Schumbera, Milena Djokic, Joelle M Strom, Jonas Schönfeld, Johanna L Geist, Feyza Polat, Toby J Gibson, Claudia Isabelle Keller Valsecchi, Manjeet Kumar, Ora Schueler-Furman, Katja Luck
Format: Article
Language:English
Published: Springer Nature 2024-01-01
Series:Molecular Systems Biology
Subjects:
AlphaFold
Protein Interaction Interface Prediction
Linear Motifs
Benchmarking
Experimental Validation
Online Access:https://doi.org/10.1038/s44320-023-00005-6

Internet

https://doi.org/10.1038/s44320-023-00005-6

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