Calcified apoptotic vesicles from PROCR+ fibroblasts initiate heterotopic ossification

Calcified apoptotic vesicles from PROCR+ fibroblasts initiate heterotopic ossification

Abstract Heterotopic ossification (HO) comprises the abnormal formation of ectopic bone in extraskeletal soft tissue. The factors that initiate HO remain elusive. Herein, we found that calcified apoptotic vesicles (apoVs) led to increased calcification and stiffness of tendon extracellular matrix (E...

Full description

Bibliographic Details
Main Authors: Jianfei Yan, Bo Gao, Chenyu Wang, Weicheng Lu, Wenpin Qin, Xiaoxiao Han, Yingying Liu, Tao Li, Zhenxing Guo, Tao Ye, Qianqian Wan, Haoqing Xu, Junjun Kang, Naining Lu, Changhe Gao, Zixuan Qin, Chi Yang, Jisi Zheng, Pei Shen, Lina Niu, Weiguo Zou, Kai Jiao
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Journal of Extracellular Vesicles
Subjects:
calcified apoptotic vesicles
extracellular matrix
heterotopic ossification
macrophage polarization
osteogenic microenvironment
Online Access:https://doi.org/10.1002/jev2.12425

Internet

https://doi.org/10.1002/jev2.12425

Similar Items