NLRP3 Inflammasome-Dependent Increases in High Mobility Group Box 1 Involved in the Cognitive Dysfunction Caused by Tau-Overexpression

NLRP3 Inflammasome-Dependent Increases in High Mobility Group Box 1 Involved in the Cognitive Dysfunction Caused by Tau-Overexpression

Tau hyperphosphorylation is a characteristic alteration present in a range of neurological conditions, such as traumatic brain injury (TBI) and neurodegenerative diseases. Treatments targeting high-mobility group box protein 1 (HMGB1) induce neuroprotective effects in these neuropathologic condition...

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Bibliographic Details
Main Authors: Yan Zhao, Si-Wei Tan, Zhi-Zhong Huang, Fa-Bo Shan, Ping Li, Ya-Lei Ning, Shi-Yang Ye, Zi-Ai Zhao, Hao Du, Ren-Ping Xiong, Nan Yang, Yan Peng, Xing Chen, Yuan-Guo Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
traumatic brain injury
high mobility group box-1
tau
NLRP3 inflammasome
spatial memory
hippocampus
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.721474/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2021.721474/full

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