Age-related self-DNA accumulation may accelerate arthritis in rats and in human rheumatoid arthritis

Age-related self-DNA accumulation may accelerate arthritis in rats and in human rheumatoid arthritis

Abstract The incidence of rheumatoid arthritis (RA) is increasing with age. DNA fragments is known to accumulate in certain autoimmune diseases, but the mechanistic relationship among ageing, DNA fragments and RA pathogenesis remain unexplored. Here we show that the accumulation of DNA fragments, in...

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Bibliographic Details
Main Authors: Wei-Dan Luo, Yu-Ping Wang, Jun Lv, Yong Liu, Yuan-Qing Qu, Xiong-Fei Xu, Li-Jun Yang, Zi-Cong Lin, Lin-Na Wang, Rui-Hong Chen, Jiu-Jie Yang, Ya-Ling Zeng, Rui-Long Zhang, Bai-Xiong Huang, Xiao-Yun Yun, Xuan-Ying Wang, Lin-Lin Song, Jian-Hui Wu, Xing-Xia Wang, Xi Chen, Wei Zhang, Hui-Miao Wang, Li-Qun Qu, Meng-Han Liu, Liang Liu, Betty Yuen Kwan Law, Vincent Kam Wai Wong
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40113-3

Internet

https://doi.org/10.1038/s41467-023-40113-3

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