LAMA4-Regulating miR-4274 and Its Host Gene SORCS2 Play a Role in IGFBP6-Dependent Effects on Phenotype of Basal-Like Breast Cancer

LAMA4-Regulating miR-4274 and Its Host Gene SORCS2 Play a Role in IGFBP6-Dependent Effects on Phenotype of Basal-Like Breast Cancer

Specificity of RNAi to selected target is challenged by off-target effects, both canonical and non-canonical. Notably, more than half of all human microRNAs are co-expressed with hosting them proteincoding genes. Here we dissect regulatory subnetwork centered on IGFBP6 gene, which is associated with...

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Bibliographic Details
Main Authors: Maxim Shkurnikov, Sergey Nikulin, Stepan Nersisyan, Andrey Poloznikov, Shan Zaidi, Ancha Baranova, Udo Schumacher, Daniel Wicklein, Alexander Tonevitsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
miRNA
TCGA
breast cancer
intragenic miRNA
laminins
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00122/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2019.00122/full

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