The role of MEK inhibition in pediatric low-grade gliomas

The role of MEK inhibition in pediatric low-grade gliomas

Pediatric low-grade gliomas (pLGGs) are the most common brain tumors in children. Many patients with unresectable tumors experience recurrence or long-term sequelae from standard chemotherapeutics. This mini-review explores the emerging role of MEK inhibitors in the management of pLGGs, highlighting...

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Bibliographic Details
Main Authors: Shehryar R. Sheikh, Laura J. Klesse, Ross Mangum, Ashley Bui, Benjamin I. Siegel, Mohamed S. Abdelbaki, Neha J. Patel
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Oncology
Subjects:
pediatric low grade glioma
PLGG
MEK
MAPK
targeted therapy
MEKi
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1503894/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2024.1503894/full

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