Development of a multiplex allele-specific qPCR approach for testing PIK3CA mutations in patients with colorectal cancer

Development of a multiplex allele-specific qPCR approach for testing PIK3CA mutations in patients with colorectal cancer

Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases involved in cellular growth and division. Somatic mutations in one of the PI3K catalytic subunit genes, PIK3CA, are frequently found in numerous malignancies, including colorectal cancer (CRC). Several PIK3CA inhibitors are approved for the tr...

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Bibliographic Details
Main Authors: Igor P. Oscorbin, Oguljan P. Beginyazova, Inna V. Khlistun, Darya V. Shamovskaya, Natalia A. Oskina, Maxim L. Filipenko
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Heliyon
Subjects:
PIK3CA
Somatic mutations
CRC
Multiplex amplification
Allele-specific PCR
ARMS
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022030924

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http://www.sciencedirect.com/science/article/pii/S2405844022030924

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