Early Estimated Glomerular Filtration Rate Trajectories After Kidney Transplant Biopsy as a Surrogate Endpoint for Graft Survival in Late Antibody-Mediated Rejection

Early Estimated Glomerular Filtration Rate Trajectories After Kidney Transplant Biopsy as a Surrogate Endpoint for Graft Survival in Late Antibody-Mediated Rejection

BackgroundLate antibody-mediated rejection (ABMR) after kidney transplantation is a major cause of long-term allograft loss with currently no proven treatment strategy. Design for trials testing treatment for late ABMR poses a major challenge as hard clinical endpoints require large sample sizes. We...

Full description

Bibliographic Details
Main Authors: Anita Borski, Alexander Kainz, Nicolas Kozakowski, Heinz Regele, Johannes Kläger, Robert Strassl, Gottfried Fischer, Ingrid Faé, Sabine Wenda, Željko Kikić, Gregor Bond, Roman Reindl-Schwaighofer, Katharina A. Mayer, Michael Eder, Markus Wahrmann, Susanne Haindl, Konstantin Doberer, Georg A. Böhmig, Farsad Eskandary
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Medicine
Subjects:
surrogate end point validation
antibody-mediated allograft rejection
landmark analysis
donor-specific anti HLA antibodies
allograft loss
estimated glomerular filtration rate (eGFR)
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.817127/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.817127/full

Similar Items