Biosynthesis of a clickable pyoverdine via in vivo enzyme engineering of an adenylation domain

Biosynthesis of a clickable pyoverdine via in vivo enzyme engineering of an adenylation domain

Abstract The engineering of non ribosomal peptide synthetases (NRPS) for new substrate specificity is a potent strategy to incorporate non-canonical amino acids into peptide sequences, thereby creating peptide diversity and broadening applications. The non-ribosomal peptide pyoverdine is the primary...

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Main Authors: Hélène Puja, Laurent Bianchetti, Johan Revol-Tissot, Nicolas Simon, Anastasiia Shatalova, Julian Nommé, Sarah Fritsch, Roland H. Stote, Gaëtan L. A. Mislin, Noëlle Potier, Annick Dejaegere, Coraline Rigouin
Format: Article
Language:English
Published: BMC 2024-07-01
Series:Microbial Cell Factories
Online Access:https://doi.org/10.1186/s12934-024-02472-4

Internet

https://doi.org/10.1186/s12934-024-02472-4

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