Development of Analytical Quality by Design Compliant Chaotropic Chromatography Method for Ziprasidone and Its Five Impurities Determination

Development of Analytical Quality by Design Compliant Chaotropic Chromatography Method for Ziprasidone and Its Five Impurities Determination

In this study, an AQbD-compliant chaotropic chromatography method for ziprasidone and the determination of its five impurities was developed. The influence of critical method parameters (initial and final methanol fraction in the mobile phase, gradient duration) on the set of selected critical metho...

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Bibliographic Details
Main Authors: Milena Rmandić, Đorđe Vasilić, Marija Rašević, Mira Zečević, Biljana Otašević, Ana Protić, Anđelija Malenović
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Pharmaceuticals
Subjects:
chaotropic chromatography
ziprasidone
impurities
analytical quality by design
robustness testing of method quantitative performances
Online Access:https://www.mdpi.com/1424-8247/16/9/1296

Internet

https://www.mdpi.com/1424-8247/16/9/1296

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