Spatial transcriptomics reveals the heterogeneity and FGG+CRP+ inflammatory cancer-associated fibroblasts replace islets in pancreatic ductal adenocarcinoma

Spatial transcriptomics reveals the heterogeneity and FGG+CRP+ inflammatory cancer-associated fibroblasts replace islets in pancreatic ductal adenocarcinoma

BackgroundUnderstanding the spatial heterogeneity of the tumor microenvironment (TME) in pancreatic cancer (PC) remains challenging.MethodsIn this study, we performed spatial transcriptomics (ST) to investigate the gene expression features across one normal pancreatic tissue, PC tissue, adjacent tum...

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Bibliographic Details
Main Authors: Zhangyong Ren, Bing Pan, Fangfei Wang, Shaocheng Lyu, Jialei Zhai, Xiumei Hu, Zhe Liu, Lixin Li, Ren Lang, Qiang He, Xin Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Oncology
Subjects:
pancreatic ductal adenocarcinoma
spatial transcriptomics
tumor microenvironment
heterogeneity
cancer-associated fibroblasts
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1112576/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1112576/full

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