PD-L1 upregulation by IFN-α/γ-mediated Stat1 suppresses anti-HBV T cell response.

PD-L1 upregulation by IFN-α/γ-mediated Stat1 suppresses anti-HBV T cell response.

Programmed death ligand 1 (PD-L1) has been recently shown to be a major obstacle to antiviral immunity by binding to its receptor programmed death 1 (PD-1) on specific IFN-γ producing T cells in chronic hepatitis B. Currently, IFN-α is widely used to treat hepatitis B virus (HBV) infection, but its...

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Bibliographic Details
Main Authors: LanLan Liu, Junwei Hou, Yuxiu Xu, Lijuan Qin, Weiwei Liu, Han Zhang, Yang Li, Mi Chen, Mengmeng Deng, Bao Zhao, Jun Hu, Huaguo Zheng, Changfei Li, Songdong Meng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0228302

Internet

https://doi.org/10.1371/journal.pone.0228302

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