Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility

Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility

Glucose-responsive insulin represents a promising approach to regulate blood glucose levels. We previously showed that attaching two fluorophenylboronic acid (FPBA) residues to the C-terminal B chain of insulin glargine led to glucose-dependent solubility. Herein, we demonstrated that relocating FPB...

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Détails bibliographiques
Auteurs principaux: Nai-Pin Lin, Nan Zheng, Landa Purushottam, Yi Wolf Zhang, Danny Hung-Chieh Chou
Format: Article
Langue:English
Publié: Frontiers Media S.A. 2022-03-01
Collection:Frontiers in Chemistry
Sujets:
insulin
glucose responsiveness
peptide
insulin modification
phenylboronate
Accès en ligne:https://www.frontiersin.org/articles/10.3389/fchem.2022.859133/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.859133/full

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